Richard Chamberlain, who rose to fame as the heartthrob star of the television series “Dr. Kildare” in the early 1960s, proved his mettle by becoming a serious stage actor and went on to a new wave of acclaim as the omnipresent leading man of 1980s mini-series, died on Saturday night at his home in Waimanalo, Hawaii, on the island of Oahu. He was 90.

A spokesman, Harlan Boll, said the cause was complications of a stroke.

Mr. Chamberlain was just 27 when he made his debut in the title role of the idealistic young intern on NBC’s “Dr. Kildare,” based on the 1930s and ’40s movie series. With his California-blond boyish good looks and low-key charm, he became an overnight star, said to be receiving 12,000 fan letters a week during the show’s five-year run (1961-66).

Not long after the series ended, he moved to England, determined to shake his pretty-boy image by training as a serious actor. By 1969 he was playing Hamlet at the Birmingham Repertory Theater and surprising the British critics, who called him assured, graceful and plucky. “Anyone who comes to this production to scoff at the sight of a popular American television actor, Richard Chamberlain, playing Hamlet will be in for a deep disappointment,” a review in The Times of London declared.

After five years he returned to the United States and to notable stage and screen roles, but it was television, and in particular the mini-series format, that restored his major star status. It began with a role as a Scottish trapper in the ensemble cast of the 12-part “Centennial” in 1978, as viewers began a brief but intense romance with this new programming form, which combined feature-film ambition with the many hours required to tell big stories in great detail.

For Mr. Chamberlain, the phenomenon hit full force only when he played the dashing 17th-century romantic lead in “Shogun” in 1980, seducing a new generation of fans. He followed that in 1983 with his portrayal of Ralph de Bricassart, the tortured young priest in the saga “The Thorn Birds,” making him a 49-year-old sex symbol and the undeniable holder of the unofficial title “king of the mini-series.”

Mr. Chamberlain received Emmy Award nominations for “The Thorn Birds” and “Shogun,” as well as for “Wallenberg: A Hero’s Story” (1985) — in which he played Raoul Wallenberg, the World War II resistance hero — and for “The Count of Monte Cristo” (1975). He won three Golden Globes during his career, for “The Thorn Birds” and “Shogun,” and as best television actor for “Dr. Kildare” in 1963.

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